Roche Genentech

Summary

Roche’s Genentech cut at least 489 jobs in 2025, including 141 layoffs in August that were only recently disclosed due to a reporting delay, on top of 348 previously known cuts. The layoffs occurred across departments and sites but were formally tied to the company’s South San Francisco headquarters for regulatory purposes. Genentech said the reductions were driven by manufacturing changes, organizational consolidation, and cuts across IT, research, and other teams, while emphasizing it is continuing to hire in areas like digital, automation, and AI and has added more than 400 new employees alongside new manufacturing investments.